|
KMID : 0043319970200010072
|
|
Archives of Pharmacal Research
1997 Volume.20 No. 1 p.72 ~ p.75
|
|
|
Synthesis and Anti-inflammatory and Analgesic Activities of Phenoxyalkanoic Acid Derivatives
|
|
Shin Kuk-Hyun
Lee Eun-Bang
Park Sang-Woo
Shin Kye-Jung
Kim Dong-Chan
Kim Dong-Jin
|
|
|
Abstract
|
|
|
|
The synthesis of phenoxyalkanoic acid derivatives and their anti-inflammatory and analgesic activities are described. Analysis of structure-activity relationships shows that in trichlorophenoxy derivatives anti-edematous potency is associated with the presence of 1-thiopropyl moiety and 2 or 40aminopyridyl moiety at position contributes to the analgesic activity.
|
|
|
KEYWORD
|
|
|
Phenoxyalkanoic acid derivatives, Anti-inflammatory activity, Analgesic activity, Carrageenin-induced paw edema, Acetic acid writhing syndrome, Tail clip pressure test
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|